Mercedes-Benz E 450 Gas Mileage (2016 - 2025): Comprehensive Fuel Economy Data

The Mercedes-Benz E 450 gas mileage is 20 to 28 miles per gallon as specified in our data below, organized by trim, option package, and model year.

For example, the 2016 Mercedes-Benz E 450 SUV GL Sport trim model has a combined gas mileage of 20 miles per gallon, while the 2025 Mercedes-Benz E 450 4MATIC has a combined gas mileage of 28 miles per gallon.

In the city, the E 450 gas mileage is 17 to 23 miles per gallon depending on the trim and model year.

On the highway, the E 450 gas mileage is 23 to 33 miles per gallon depending on the trim and model year.

Note: The gas mileage shown for hybrid vehicles is the miles per gallon equivalent.

Check out the Gas Mileage specifications for other makes and models.

2025 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2025 Mercedes-Benz E 450 gas mileage is from 27 to 28 miles per gallon combined.

In the city, the 2025 E 450 gas mileage is from 22 to 23 miles per gallon, depending on the trim.

On the highway, the 2025 E 450 gas mileage is from 31 to 33 miles per gallon, depending on the trim.

2024 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2024 Mercedes-Benz E 450 gas mileage is from 27 to 28 miles per gallon combined.

In the city, the 2024 E 450 gas mileage is from 22 to 23 miles per gallon, depending on the trim.

On the highway, the 2024 E 450 gas mileage is from 31 to 33 miles per gallon, depending on the trim.

2023 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2023 Mercedes-Benz E 450 gas mileage is from 22.5 to 27 miles per gallon combined.

In the city, the 2023 E 450 gas mileage is from 20 to 23 miles per gallon, depending on the trim.

On the highway, the 2023 E 450 gas mileage is from 25 to 31 miles per gallon, depending on the trim.

2022 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2022 Mercedes-Benz E 450 gas mileage is from 22.5 to 26.5 miles per gallon combined.

In the city, the 2022 E 450 gas mileage is from 20 to 23 miles per gallon, depending on the trim.

On the highway, the 2022 E 450 gas mileage is from 25 to 30 miles per gallon, depending on the trim.

2021 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2021 Mercedes-Benz E 450 gas mileage is from 23.5 to 27 miles per gallon combined.

In the city, the 2021 E 450 gas mileage is from 21 to 23 miles per gallon, depending on the trim.

On the highway, the 2021 E 450 gas mileage is from 26 to 31 miles per gallon, depending on the trim.

2020 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2020 Mercedes-Benz E 450 gas mileage is from 21.5 to 24 miles per gallon combined.

In the city, the 2020 E 450 gas mileage is from 19 to 20 miles per gallon, depending on the trim.

On the highway, the 2020 E 450 gas mileage is from 24 to 28 miles per gallon, depending on the trim.

2019 Mercedes-Benz E 450 Gas Mileage

Depending on trim level, the 2019 Mercedes-Benz E 450 gas mileage is from 22.5 to 24 miles per gallon combined.

In the city, the 2019 E 450 gas mileage is from 19 to 20 miles per gallon, depending on the trim.

On the highway, the 2019 E 450 gas mileage is from 26 to 28 miles per gallon, depending on the trim.

2016 Mercedes-Benz E 450 Gas Mileage

The 2016 Mercedes-Benz E 450 gas mileage is 20 miles per gallon combined.

In the city, the 2016 E 450 gas mileage is 17 miles per gallon.

On the highway, the 2016 E 450 gas mileage is 23 miles per gallon.